He cannot use his weapon in them.but that's okay, nothing will attack you in them.
Air-Vent Passageway: Isaac can climb into some Jefferies Tubes at certain points. While her attempts to impede Isaac are an aversion, since he's actively circumventing normal security procedures, she was very much malfunctioning before the necromorph outbreak began. You would expect the stores to at least let you run up a debt, but no. Adam Smith Hates Your Guts: Present and prevalent as ever, with Isaac's survival dependent on the Sprawl's plentiful automated stores which happily cough up lethal weaponry and heavy armour in exchange for stolen credits, despite the unfolding crisis situation engulfing the station. He still is determined to survive, and manages to use modified tools and his environment to overcome impossible odds, including things like overcoming a small army of security guards waiting for him. He's not a trained soldier, just an engineer. Action Survivor: Isaac seems to be this to some degree.Actionized Sequel: While the original isn't lacking in action, the sequel ramps up the scale of the set-pieces and speed of the pacing a lot.It's not abandoned at the time, but by the time you gain control, it's smack in the middle of the Necromorph infestation and thus devoid of human survivors. Abandoned Hospital Awakening: The game begins with Isaac waking up in a hospital on the Sprawl.
Abandoned Area: Pretty much everywhere you visit is either already abandoned or will be in very short order.